Mindless Behavior 'Definitely Unique' Among Boy Bands

'Our Mindless movement is all about being confident, just being yourself,' Battle of the Boy Bands hopefuls tell MTV News.
By Kelly Marino

Mindless Behavior
Photo: Getty Images

The first round of MTV News' Battle of the Boy Bands has officially ended, but there is still time for fans to cast their votes for their favorite heartthrob group in hopes to title them the ultimate boy band of all time.

Another group urging their biggest followers to vote for them are the guys from Mindless Behavior. But before you get mindless with your votes, here are some facts about the foursome that might help steer your mind in the right direction:

Highest Chart Achievement
Their single "Mrs. Right" featuring rapper Diggy Simmons reached #8 on the U.S. Billboard R&B/Hip-Hop charts after its 2011 release.

Defining Tune
The guys confess they would travel the world just to find the right kind of girl in the beat-popping hit "Mrs. Right," causing female hearts in every country to flutter.

Standout Video
During their pledge to search high and low for "Mrs. Right," the boys get a lesson or two in geography from their teacher, Professor LL Cool J. Directed by Brett Ratner, the video also features Mike Epps as the school janitor, who joins in on the fun during a pep rally to cheer on Diggy Simmons and the group's signature dance moves.

Debut Album
Their debut album, #1 Girl, hit the U.S. in September 2011, debuting at #7 on the Billboard 200 with 36,000 copies sold in its first week.

Biggest Competition
Despite all of their success, the boys weren't afraid to admit who they thought might be their biggest competition amid the new wave of boy bands that has exploded on the scene. "As far as other boy bands who I feel [are] our biggest competition is One Direction and the Wanted," Roc Royal told us. "That's a huge competition for us, because we all have different movements, and they come from the U.K., and they also have fans out here, which, they have a lot of fans out here, so it's crazy."

So why do the guys think they should win our Battle of the Boys Band? Well, it's simple, really: "There's a lot of boy bands in the poll, but we're definitely unique," Princeton stated. "So please vote for us."

Ray Ray chimed in: "I think we should win the title for Best Boy Band of All Time because we have a great movement. Our Mindless movement is all about being confident, just being yourself, not caring what other people think, stopping all the bullying and, one, we're really great artists. We have songs that anyone can listen to. That's why I think we should win."

"And we love all of the fans," Princeton added.

When it comes to learning the key to becoming a great boy band, the group even filled us in on a little secret the Backstreet Boys once told them while on tour together: "When we were on tour with the Backstreet Boys, the advice that they gave us was 'Stick together no matter what,' " Ray Ray shared. "They said: You might have arguments here and there, but just stick together. You have to become family although you're in a group. You have to literally become family, and you got to stick together."

Voting in round two of MTV's Battle of the Boy Bands runs until noon ET on Monday, April 30. Winners are determined by fan votes, so if your favorite band made the cut, make sure you keep voting. Tune in to AMTV and MTV Hits for their boy-band video takeovers each day and make sure to spread the word on Twitter using the hashtag #BBB and like us on Facebook for updates!

Vote for your favorite band, discuss and share on Facebook and Twitter in the MTV Battle of the Boy Bands interactive bracket!

Related Videos

• Battle Of The Boy Bands

Related Artists

• Mindless Behavior

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Android Central 94: The Galaxy S III cometh, even more on HTC One, Google Drive lives!

Podcast MP3 URL: 

http://traffic.libsyn.com/androidcentral/acpc94.mp3

 

Thing 1: The 'Next Galaxy' is nigh!

• Samsung announces the Exynos 4 Quad, coming to the 'next Galaxy'
• Dual-core Galaxy S3 to be offered in some territories with Snapdragon S4 and LTE
• Purported Samsung Galaxy S3 service manual and device render leak online
• Galaxy S3 spotted in Samsung Kies software
• Late-night poll: What will Samsung call its new flagship phone?
• Another 'Next Galaxy' dummy unit appears, throws Android style guide to the wind
• O2 confirms it'll stock 'next Galaxy', references to 'Galaxy S3' in official app keep us guessing
• Samsung Unpacked 2012 app now available from Google Play, offers usual slim pickings ahead of event

Thing 2: T-Mobile HTC One S now available, One X up next on AT&T

• AC forum member goes hands-on with the AT&T HTC One X
• AT&T HTC One X will have free Dropbox space, company spokeswoman affirms
• HTC One S review (T-Mobile US)
• HTC One S available today on T-Mobile
• Ask AC: The T-Mobile HTC One S uses Carrier IQ?

Thing 3: Google Drive is here

• Google Drive cloud storage service launches, 5GB free space for all
• Gmail free storage upped to 10GB, 25GB for paying Google Drive customers
• Google Docs is now Google Drive - we take it for a spin
• Late-night poll: Did you set up your Google Drive?

Thing 4: Best of the rest

• ASUS Transformer Pad TF300 review
• Galaxy Nexus, Viper and Optimus Elite now available on Sprint
• Don't forget: You could win this brand-new Samsung Galaxy Nexus!
• Facebook for Android updated with new icons for Camera and Messenger

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Biden knocks Romney for "back to the future" foreign policy (reuters)

Share With Friends: | | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

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Sarah Michelle Gellar & Freddie Prinze Jr. Expecting Second Child!

Sarah Michelle Gellar & Freddie Prinze Jr. Expecting Second Child!

Acting couple Sarah Michelle Gellar and husband Freddie Prinze, Jr. have their second child on the way. The couple, who met on the set of [...]

Sarah Michelle Gellar & Freddie Prinze Jr. Expecting Second Child! Stupid Celebrities Gossip Stupid Celebrities Gossip News

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Shun's Hiro Santoku is the Only Knife a Cook Needs [Daily Desired]

If you're cooking with a mediocre knife, you don't know what you're missing until you use one that's really top-notch. It's a whole different game. Shun makes some of the highest-quality cutlery, and its new Hiro Santoku will have you slicing like a pro. More »

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Facebook Ads Can Now Be Optimized To Drive Any On-Facebook Action, Such As In-App Purchases, Shares, Offer Claims

Marketers don't actually want clicks, they want the downstream conversions and the return on investment that follow. So today Facebook begins allowing advertisers using its API to ask it to show their ads to people most likely to take any specific post-click action on the social network, such as sharing a brand's content to the news feed, buying virtual goods in their apps, or redeeming one of the new Facebook Offers at a local brick-and-mortar store. Previously Facebook's Ads API and self-serve tool only permitted optimization for clicks, Page Likes, app installs, and check-ins. Data on conversions 1, 7, or 28 days after a click will now appear in the Ads Manager. Rather than having to deduce what demographics are most likely to convert, and being unable to tell if those conversions came straight from ads, today's improvements give advertisers more transparency, and will make it easier for a much wider range of businesses like social games, local businesses, and big brands to earn money from Facebook marketing.

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Study dusts sugar coating off little-known regulation in cells

Tuesday, April 17, 2012

In Alzheimer's disease, brain neurons become clogged with tangled proteins. Scientists suspect these tangles arise partly due to malfunctions in a little-known regulatory system within cells. Now, researchers have dramatically increased what they know about this particular regulatory system in mice. Such information will help scientists better understand Alzheimer's and other diseases in humans and could eventually provide new targets for therapies.

In a study released online in the Proceedings of the National Academy of Sciences Early Edition this week, the team at least doubled the number of proteins found to be subject to a type of regulation based on a sugar known as O-GlcNAc (oh-GLIK-nak). The O-GlcNAc system likely adds another layer of control to the proteins that serve as a brain cell's widgets and gears -- control that might be muddled in Alzheimer's brains known to have problems in sugar metabolism.

"We found many novel proteins providing insights into new aspects of cell biology," said analytical biochemist Feng Yang of the Department of Energy's Pacific Northwest National Laboratory and lead author on the study. "We think O-GlcNAc is fine-tuning cellular processes."

In addition to finding hundreds of proteins modified by O-GlcNAc, the team found that almost all the O-GlcNAc proteins were also subject to the most common form of protein regulation, which uses small phosphate molecules to turn proteins on and off. This suggests a larger coordination between the two regulatory systems.

"These results show there's a level of complexity about how biology operates that we've been largely blind to," said PNNL's Richard D. Smith, who leads the proteomics team at PNNL. Proteomics researchers try to understand how a cell functions based on the numbers and types of its proteins at work, which are collectively known as the proteome (PRO-tee-ohm).

"Back during the Human Genome Project, we asked, how could so few genes produce the complexity of an organism or even a single cell, and how could minor variations in our DNA explain the diversity we see all around us? Clearly the proteome is the answer," said Smith.

Sugar Switch

Proteins are the tools, gears and gadgets that run a cell. Regulatory systems within cells turn proteins on and off by attaching or detaching small molecules to the proteins, like a switch. The most common switch involve adding or removing phosphates, and biologists have known for a long time that these switches can run amiss in cancer and other diseases. Drugs affect players in the phosphate regulatory system to try to fix the errors.

A couple decades ago, researchers found that O-GlcNAc, a kind of sugar, could also work like a switch, turning proteins on or off. Scientists found proteins decorated by O-GlcNAc, as well as other proteins that attach or remove the sugar -- all essential parts to the system.

But they had trouble finding enough O-GlcNAc proteins to get the whole story. Few proteins bore the small sugar, and those that did tended to lose the accessory while being manhandled in the lab. Researchers could make up for some of these problems by starting with more tissue or cultured cells, but they knew if they wanted to look for these modifications in real-life scenarios such as clinical samples, they would need to be able to find the sugar with a small amount of starting material.

To overcome these difficulties, Smith, Yang and their colleagues at PNNL and four research institutions combined their expertise in the O-GlcNAc system with instruments developed at EMSL, DOE's Environmental Molecular Sciences Laboratory on the PNNL campus. First they improved how they purified protein from mouse brain tissue to reinforce the sugar attached to proteins. Then they used instruments that exceled at detecting rare proteins in small samples.

In addition, they looked for the sugar-dotted proteins in mouse brain samples from engineered animals that had a mouse version of Alzheimer's. These mice make too much of three key proteins implicated in Alzheimer's disease in people, including the Tau protein, which forms the hallmark tangles in brain neurons.

Pack o' Proteins

To test how well their methods found O-GlcNAc proteins, the PNNL-led team started with tissue from either healthy or diseased mouse brain tissue. From the healthy tissue, the team found 274 different proteins marked with O-GlcNAc. Many of them sported more than one sugar molecule, because the team found a total of 458 attachment sites on those 274 proteins -- triple the number of sites found in any previous study. The large number of sites allowed the team to identify similarities between O-GlcNAc sites, as well as O-GlcNAc sites on previously unexplored proteins.

Of the 274 O-GlcNAc proteins, 106 had already been identified in other studies. That left 168 newly-identified proteins. Based on what the proteins looked like, the team classified most of them as likely being involved in cell signaling, regulating how genes are expressed, or, again, in cell scaffolding.

The O-GlcNAc-dabbed proteins held a variety of jobs, including forming part of a cell's scaffolding, or in nerve growth or in other nerve-related occupations such as learning and memory.

The PNNL-led team then looked at the proteins found in the Alzheimer's-like mouse brain. They found about a third fewer O-GlcNAc-marked proteins. That result also supports earlier work that suggested there is damaged O-GlcNAc regulation in Alzheimer's brains in people.

Fraternizing Phosphates and Other Biology

One of the more exciting things the researchers found had to do with the most common regulatory system in cells, the phosphate system. More than 98 percent of the O-GlcNAc proteins also had sites that would accept a phosphate, suggesting those proteins are also under the control of that system.

And about a quarter of the O-GlcNAc sites were close enough to the phosphate sites to interfere with that switch, suggesting cross-talk between the two types of regulation. A phosphate is smaller than O-GlcNAc and has a strong negative electrical charge. The sugar is neutral but bulkier. Those characteristics could have different effects on the structure of the protein and greatly increases the range of possible biological effects due to the complexity of the combined switching systems.

Lastly, until this study, most of the proteins known to be under O-GlcNAc control largely live their lives within the cells. But the PNNL-led team found a half-dozen proteins that had to be controlled by O-GlcNAc outside a cell, based on where their O-GlcNAc site fell on the body of the protein.

Now, the team is planning to measure both regulatory systems in concert.

"It's revealing to see how many proteins are modified. If we're going to understand biological systems, we need to understand the interplay of the different types of modifications," said Smith.

###

DOE/Pacific Northwest National Laboratory: http://www.pnnl.gov/news

Thanks to DOE/Pacific Northwest National Laboratory for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Social Media Management: Knowing the Right Social Media ...

Social Media Management: Knowing the Right Social Media Management Company

April 17th, 2012 by admin

If you look around nowadays, you?ll discover so many social media management companies. But who?s genuine, and who?s just a poser? It can be difficult to tell with every other person and their mother declaring to be a social media professional nowadays. Search on the internet for popularity signs and testimonials / situation research. Look who they follow and evaluate their internet existence. Are they legitimate or just a bogus? Don?t go for the most affordable guy on the block either. Usually when it comes to social media management, you get what you pay for usually. You cannot assume someone that?s never developed a company with social media to be able to show you how to do the same.

Posted in Internet and Businesses Online | Comments Off

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